ParkinsonCanadaV1, Main, Exploration, bibRecord, 003817

Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease

Identifieur interne : 003817 ( Main/Exploration ); précédent : 003816; suivant : 003818

Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease

Auteurs : R. A. Hauser [États-Unis] ; T. B. Freeman [États-Unis] ; B. J. Snow [Canada] ; M. Nauert [États-Unis] ; L. Gauger [États-Unis] ; J. H. Kordower [États-Unis] ; C. W. Olanow [États-Unis]

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 1999.

RBID : Pascal:99-0381130

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stade avancé, Survie, Greffe, Bilatéral, Putamen, Locus niger, Neurone, Foetus, Dyskinésie, Tomoscintigraphie, Positon, Fluorodopa(18F), Protocole thérapeutique, Traitement, Long terme, Evolution, Adulte, Mâle, Femelle.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Advanced stage, Bilateral, Dyskinesia, Emission tomography, Evolution, Female, Fetus, Fluorodopa(18F), Graft, Locus niger, Long term, Male, Neuron, Parkinson disease, Positron, Putamen, Survival, Therapeutic protocol, Treatment.

Abstract

Background: Parkinson disease (PD) is associated with a progressive loss of nigrostriatal dopamine neurons. Medication therapy provides adequate control of symptoms for several years, but long-term treatment is complicated by progressive disability and the development of motor fluctuations and dyskinesias. In animal models of PD, fetal nigral transplants have been shown to survive grafting into the striatum, provide extensive striatal reinnervation, and improve motor function. In patients with PD, cell survival and clinical benefit have been observed following fetal nigral grafting, but results have been inconsistent. Objective: To evaluate the safety and efficacy of bilateral fetal nigral transplantation into the postcommissural putamen in patients with advanced PD complicated by motor fluctuations and dyskinesias. Patients and Methods: Six patients with advanced PD underwent bilateral fetal nigral transplantation. Each patient received solid grafts derived from donors aged 61/2 to 9 weeks after conception stereotactically implanted into the postcommissural putamen using 3 to 4 donors per side. Cyclosporine was administered for approximately 6 months to provide immune suppression.(...)

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Advanced stage</term>
<term>Bilateral</term>
<term>Dyskinesia</term>
<term>Emission tomography</term>
<term>Evolution</term>
<term>Female</term>
<term>Fetus</term>
<term>Fluorodopa(18F)</term>
<term>Graft</term>
<term>Locus niger</term>
<term>Long term</term>
<term>Male</term>
<term>Neuron</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Putamen</term>
<term>Survival</term>
<term>Therapeutic protocol</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stade avancé</term>
<term>Survie</term>
<term>Greffe</term>
<term>Bilatéral</term>
<term>Putamen</term>
<term>Locus niger</term>
<term>Neurone</term>
<term>Foetus</term>
<term>Dyskinésie</term>
<term>Tomoscintigraphie</term>
<term>Positon</term>
<term>Fluorodopa(18F)</term>
<term>Protocole thérapeutique</term>
<term>Traitement</term>
<term>Long terme</term>
<term>Evolution</term>
<term>Adulte</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Background: Parkinson disease (PD) is associated with a progressive loss of nigrostriatal dopamine neurons. Medication therapy provides adequate control of symptoms for several years, but long-term treatment is complicated by progressive disability and the development of motor fluctuations and dyskinesias. In animal models of PD, fetal nigral transplants have been shown to survive grafting into the striatum, provide extensive striatal reinnervation, and improve motor function. In patients with PD, cell survival and clinical benefit have been observed following fetal nigral grafting, but results have been inconsistent. Objective: To evaluate the safety and efficacy of bilateral fetal nigral transplantation into the postcommissural putamen in patients with advanced PD complicated by motor fluctuations and dyskinesias. Patients and Methods: Six patients with advanced PD underwent bilateral fetal nigral transplantation. Each patient received solid grafts derived from donors aged 61/2 to 9 weeks after conception stereotactically implanted into the postcommissural putamen using 3 to 4 donors per side. Cyclosporine was administered for approximately 6 months to provide immune suppression.(...)</div>
</front>
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<name sortKey="Olanow, C W" sort="Olanow, C W" uniqKey="Olanow C" first="C. W." last="Olanow">C. W. Olanow</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease

Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri